Date of publication: 2017-09-03 09:14
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Most vaccines are currently administered by healthcare personnel using a needle and syringe. This delivery method poses significant hurdles in vaccine delivery, especially in developing countries. We propose dissolving microneedle patches to be a suitable alternative to needle and syringe vaccination in developing countries. Dissolving microneedle patches contain micron sized needles made out of water-soluble biodegradable polymers that dissolve in the skin to deliver the vaccine. They offer the simplicity of patch application and the possibility to mitigate the logistical and safety challenges associated with conventional hypodermic needles.
The central hypothesis was that rabies vaccine can be stabilized in a dissolving microneedle patch and be at least as immunogenic as conventional needle and syringe while enabling simple administration and that dissolving microneedle patches could be easily administered without the need of an applicator, be well tolerated in the skin and preferred over needle and syringe administration. This was assessed by engineering patches for veterinary rabies vaccination and evaluating immune response in dogs and determining tolerability, usability and acceptability of placebo microneedle patches in human subjects. Altogether, the results from this thesis should further clinical translation of microneedles for vaccination in developing countries.
ABOUTME , BRAND ANTHONYCRASTO , COLLECTION OF SITE LINKS , BRAVESITES , GRAVATAR , JIMDO , SKILLPAGES , MIXXT , APNACIRCLE , ZIC ZAC , ZING ME , SCOOP IT , scribd , Stumbleupon , Delicious , pinnterest , tumblr , Newsvine , SLIDESHARE , , GOOGLE PLUS , FACEBOOK , TWITTER , ISSUU , DIIGO , YOLASITE ,
Prior to joining Glenmark, he worked with major multinationals like Hoechst Marion Roussel, now Sanofi Aventis, & Searle India ltd, now RPG lifesciences, etc. He has worked in Basic research, Neutraceuticals, Natural products, Flavors, Fragrances, Pheromones, Vet Drugs, Drugs, formulation, GMP etc. He has total 79 yrs exp in this field, he is now helping millions, has million hits on google on all organic chemistry websites.
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PhD Thesis Title : Synthesis of Natural product-inspired Macrocyclic Architectures and Hybrid Latrunculins.
PhD degree awarded, University of Hyderabad, Dec 7569.
DR ANTHONY MELVIN CRASTO , Born in Mumbai in 6969 and graduated from Mumbai University, Completed his PhD from ICT ,6996, Mumbai, India in Organic chemistry, The thesis topic was Synthesis of Novel Pyrethroid Analogues,